CENPU Q71F23

着丝粒蛋白 U (CENP-U) (50 kDa 着丝粒蛋白) (CENP-50) (间期着丝粒复合体蛋白 24) (KSHV 潜伏核抗原相互作用蛋白 1) (MLF1 相互作用蛋白) (Polo-box 相互作用蛋白 1)

功能描述

CENPA-NAC（核小体相关）复合物的组分，该复合物在动粒蛋白组装、有丝分裂进程和染色体分离中发挥核心作用。CENPA-NAC复合物招募CENPA-CAD（核小体远端）复合物，并可能参与新合成的CENPA整合到着丝粒中。在PLK1正确定位到有丝分裂动粒中起重要作用。作为一种支架蛋白，负责动粒PLK1群体的初始招募和维持，直到其降解。参与转录抑制。{ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}。

组织特异性

Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.

亚细胞定位

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.