着丝粒蛋白M (CENP-M) (间期着丝粒复合体蛋白39) (增殖相关核元件蛋白1)
着丝粒蛋白M (CENP-M) (间期着丝粒复合体蛋白39) (增殖相关核元件蛋白1)
Q9NSP4功能描述
CENPA-NAC（核小体相关）复合物的组分，该复合物在动粒蛋白组装、有丝分裂进程和染色体分离中发挥核心作用。CENPA-NAC复合物招募CENPA-CAD（核小体远端）复合物，可能参与新合成的CENPA整合到着丝粒中。 {ECO:0000269|PubMed:16716197}。
组织特异性
Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.
亚细胞定位
Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres.
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