CELA2A P08217

胰凝乳蛋白酶样弹性蛋白酶家族成员2A (EC 3.4.21.71) (Elastase-2A)

功能描述

弹性蛋白酶，增强胰岛素信号传导，可能在细胞葡萄糖代谢中具有生理作用。在血浆中循环，减少血小板过度激活，触发胰岛素分泌和降解，并增加胰岛素敏感性。{ECO:0000269|PubMed:31358993}。

组织特异性

Expressed in pancreas. Not detected in keratinocytes (PubMed:10620133). Detected in exocrine secretions of the pancreas (at protein level). Also expressed in a small fraction of cells in pancreatic islets, adrenal cortex, intestinal glands and colonic lymphoid follicles (at protein level) (PubMed:31358993). Detected in plasma (PubMed:31358993).

亚细胞定位

Secreted