CEL P19835

胆盐激活脂肪酶 (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (胆盐刺激性脂肪酶) (BSSL) (Bucelipase) (羧基酯脂肪酶) (胆固醇酯酶) (胰腺溶血磷脂酶) (固醇酯酶)

蛋白质信息 (UniProt)

胆盐激活脂肪酶 (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (胆盐刺激性脂肪酶) (BSSL) (Bucelipase) (羧基酯脂肪酶) (胆固醇酯酶) (胰腺溶血磷脂酶) (固醇酯酶)

P19835

功能描述

催化多种底物的水解，包括胆固醇酯、磷脂、溶血磷脂、二酰甘油和三酰甘油，以及羟基脂肪酸脂肪酸酯 (FAHFAs) (PubMed:10220579, PubMed:27509211, PubMed:27650499, PubMed:8471055)。优先水解酯键距离羧基较远的 FAHFAs。不饱和 FAHFAs 比饱和 FAHFAs 水解更快 (By similarity)。在膳食脂质的完全消化及其肠道吸收以及脂溶性维生素的吸收中发挥重要作用 (PubMed:10220579, PubMed:27509211, PubMed:27650499, PubMed:8471055)。 {ECO:0000250|UniProtKB:Q64285, ECO:0000269|PubMed:10220579, ECO:0000269|PubMed:27509211, ECO:0000269|PubMed:27650499, ECO:0000269|PubMed:8471055}。

组织特异性

Mammary gland and pancreas. Detected in pancreatic and duodenal juice (at protein level) (PubMed:21784842). Expressed by eosinophils.

亚细胞定位

Secreted

关键词

3D-structure Alternative splicing Diabetes mellitus Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lipid degradation Lipid metabolism Proteomics identification

外部链接

UniProt: P19835

NCBI Gene

GeneCards