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CDKN1C P49918

细胞周期蛋白依赖性激酶抑制剂1C (细胞周期蛋白依赖性激酶抑制剂p57) (p57Kip2)

蛋白质信息 (UniProt)

细胞周期蛋白依赖性激酶抑制剂1C (细胞周期蛋白依赖性激酶抑制剂p57) (p57Kip2)

P49918

功能描述

多种G1 cyclin/CDK复合物(cyclin E-CDK2、cyclin D2-CDK4和cyclin A-CDK2)以及较小程度上有丝分裂cyclin B-CDC2的强效紧密结合抑制剂。细胞增殖的负调控因子。可能在维持终生非增殖状态中发挥作用。

组织特异性

Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

亚细胞定位

Nucleus

关键词

Alternative splicing Cell cycle Disease variant Methylation Nucleus Phosphoprotein Protein kinase inhibitor Proteomics identification Reference proteome Repeat