CDIPT O14735

CDP-二酰甘油-肌醇3-磷酸转移酶 (EC 2.7.8.11) (磷脂酰肌醇合酶) (PI synthase) (PtdIns synthase)

功能描述

催化磷脂酰肌醇(PtdIns)的生物合成以及PtdIns:肌醇交换反应。因此可能起到降低细胞内过量PtdIns含量的作用。该交换活性归因于PtdIns合酶的逆反应，并且依赖于紧密结合在该酶上的CMP。{ECO:0000269|PubMed:8110188, ECO:0000269|PubMed:9407135}。

组织特异性

Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain.

亚细胞定位

Endoplasmic reticulum membrane