CDC42小效应蛋白2 (CDC42蛋白小效应因子2)
CDC42小效应蛋白2 (CDC42蛋白小效应因子2)
Q9NRR3功能描述
可能通过作用于CDC42下游参与肌动蛋白细胞骨架的组织，诱导肌动蛋白丝组装。改变CDC42诱导的细胞形态变化。在活化的T细胞中，可能在CDC42介导的免疫突触处F-肌动蛋白积累中发挥作用。可能在巨噬细胞吞噬作用的早期收缩事件中发挥作用。 {ECO:0000269|PubMed:10816584, ECO:0000269|PubMed:15840583}.
组织特异性
Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).
亚细胞定位
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
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