CD68 P34810

巨唾液蛋白 (Gp110) (CD抗原 CD68)

功能描述

可能在组织巨噬细胞的吞噬活动中发挥作用，包括细胞内溶酶体代谢以及细胞-细胞和细胞-病原体的胞外相互作用。结合组织及器官特异性凝集素或选择素，使巨噬细胞亚群归巢至特定部位。CD68从内体和溶酶体到质膜的快速再循环可能允许巨噬细胞在选择素 bearing 底物或其他细胞上爬行。

组织特异性

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

亚细胞定位

[Isoform Short]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.