CD6 P30203

T细胞分化抗原CD6 (T12) (TP120) (CD抗原CD6) [剪切为：可溶性CD6]

功能描述

细胞粘附分子，通过与ALCAM/CD166相互作用介导细胞-细胞接触并调节T细胞反应 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728)。参与由TCR/CD3复合物激活引发的信号级联反应 (PubMed:24584089)。作为共刺激分子发挥作用；促进T细胞活化和增殖 (PubMed:15294938, PubMed:16352806, PubMed:16914752)。参与免疫突触的形成和成熟 (PubMed:15294938, PubMed:16352806)。作为钙依赖性模式受体发挥作用，结合并聚集革兰氏阳性和革兰氏阴性细菌。既结合革兰氏阴性细菌的脂多糖 (LPS)，也结合革兰氏阳性细菌的脂磷壁酸 (PubMed:17601777)。LPS结合导致信号级联反应和下游MAP激酶的激活 (PubMed:17601777)。介导炎症反应的激活以及响应LPS的促炎细胞因子分泌 (PubMed:17601777)。 {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}。

组织特异性

Detected on thymocytes (PubMed:15294938). Detected on peripheral blood T-cells (PubMed:15048703, PubMed:16352806). Detected on natural killer (NK) cells (PubMed:16352806). Soluble CD6 is detected in blood serum (at protein level) (PubMed:17601777). Detected in spleen, thymus, appendix, lymph node and peripheral blood leukocytes (PubMed:9013954). Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

亚细胞定位

Cell membrane