CD177 Q8N6Q3

CD177抗原 (人类中性粒细胞同种抗原2a) (HNA-2a) (NB1糖蛋白) (NB1 GP) (真性红细胞增多症蛋白1) (PRV-1) (CD抗原CD177)

功能描述

与beta-2整合素异二聚体ITGAM/CD11b和ITGB2/CD18结合，介导TNF引发的嗜中性粒细胞的激活，包括脱颗粒和超氧化物产生 (PubMed:21193407)。此外，通过阻止beta-2整合素内化并减弱趋化因子信号传导，促进粘附优于迁移 (PubMed:28807980)。与内皮细胞上PECAM1的异嗜性相互作用在体外嗜中性粒细胞跨内皮迁移中起作用 (PubMed:17580308)。然而，对于体内细菌感染引起的嗜中性粒细胞募集似乎是非必需的 (PubMed:23461681)。作为蛋白酶PRTN3成熟形式的受体，使其展示在嗜中性粒细胞表面 (PubMed:17244676, PubMed:18462208)。通过在嗜中性粒细胞表面展示PRTN3，可能在嗜中性粒细胞渗出过程中增强内皮细胞连接完整性从而维持血管完整性方面发挥作用 (PubMed:23202369)。 {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:17580308, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:23461681, ECO:0000269|PubMed:28807980}.

组织特异性

Highly expressed in normal bone marrow and weakly expressed in fetal liver (PubMed:10753836). During neutrophil differentiation, expression begins at the metamyelocyte stage and continues throughout the subsequent stages (at protein level) (PubMed:17244676, PubMed:18462208, PubMed:24926686). Expressed by a subset of mature neutrophils (at protein level) (PubMed:10753836, PubMed:12377969, PubMed:12675722, PubMed:17244676, PubMed:17580308, PubMed:18462208, PubMed:21193407, PubMed:24926686, PubMed:27227454, PubMed:28240246, PubMed:28807980). The percentage of neutrophils expressing CD177 varies across the population (PubMed:17244676, PubMed:27227454). Expressed in granulocytes of patients with polycythemia vera (PV) and with essential thrombocythemia (ET) (PubMed:10753836, PubMed:12377969).

亚细胞定位

Cell membrane