唾液黏蛋白核心蛋白 24 (MUC-24) (Endolyn) (多糖基化核心蛋白 24) (MGC-24) (MGC-24v) (CD抗原 CD164)
唾液黏蛋白核心蛋白 24 (MUC-24) (Endolyn) (多糖基化核心蛋白 24) (MGC-24) (MGC-24v) (CD抗原 CD164)
Q04900功能描述
唾液粘蛋白，可能通过促进CD34(+)细胞与基质的粘附以及负向调节CD34(+)CD38(lo/-)细胞增殖，在造血过程中发挥关键作用。调节脐带血CD133+细胞的迁移，这一过程通过CXCL12/CXCR4轴介导。可能在前列腺癌转移及癌细胞浸润骨髓中起重要作用。通过增强依赖CXCR4的细胞运动性促进肌生成。正向调节成肌细胞迁移并促进成肌细胞融合为肌管（通过相似性）。{ECO:0000250|UniProtKB:Q9R0L9, ECO:0000269|PubMed:16859559, ECO:0000269|PubMed:17077324, ECO:0000269|PubMed:9763543}。
组织特异性
Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.
亚细胞定位
Lysosome membrane
关键词