CCNL1 Q9UK58

细胞周期蛋白-L1 (Cyclin-L)

蛋白质信息 (UniProt)

细胞周期蛋白-L1 (Cyclin-L)

Q9UK58

功能描述

cyclin-L-CDK11复合物的调节组分，该复合物调节转录和pre-mRNA剪接 (PubMed:11980906, PubMed:18216018, PubMed:38059508)。受CDK特异性抑制剂CDKN1A/p21抑制 (PubMed:11980906)。可能是头颈部鳞状细胞癌 (HNSCC) 中的候选原癌基因 (PubMed:12414649, PubMed:15700036)。 {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:38059508}。

组织特异性

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).

亚细胞定位

Nucleus speckle

关键词

Alternative splicing Cyclin Host-virus interaction Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Proto-oncogene

外部链接

UniProt: Q9UK58

NCBI Gene

GeneCards