CCN4 O95388

CCN家族成员4 (WNT1诱导信号通路蛋白1) (WISP-1) (Wnt-1诱导分泌蛋白)

功能描述

Wnt/Frizzled信号通路的下游调节因子。与细胞存活相关。通过激活AKT激酶减弱DNA损伤应答中p53介导的细胞凋亡。上调抗凋亡Bcl-X(L)蛋白。粘附于皮肤和黑色素瘤成纤维细胞。在体外与皮肤成纤维细胞的结合通过蛋白聚糖、decorin和biglycan发生。 {ECO:0000269|PubMed:10716946, ECO:0000269|PubMed:11782444}。

组织特异性

Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer and colon tumors. Isoform 2 is overexpressed in scirrhous gastric carcinoma.

亚细胞定位

Secreted.