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CCL23 P55773

C-C基序趋化因子23 (CK-beta-8) (CKB-8) (巨噬细胞炎性蛋白3) (MIP-3) (髓系祖细胞抑制因子1) (MPIF-1) (小诱导细胞因子A23) [裂解为: CCL23(19-99); CCL23(22-99); CCL23(27-99); CCL23(30-99)]

蛋白质信息 (UniProt)

C-C基序趋化因子23 (CK-beta-8) (CKB-8) (巨噬细胞炎性蛋白3) (MIP-3) (髓系祖细胞抑制因子1) (MPIF-1) (小诱导细胞因子A23) [裂解为: CCL23(19-99); CCL23(22-99); CCL23(27-99); CCL23(30-99)]

P55773

功能描述

对单核细胞、静息T淋巴细胞和嗜中性粒细胞显示趋化活性,但对活化淋巴细胞无趋化活性。在集落形成实验中抑制髓系祖细胞的增殖。该蛋白能结合肝素。结合CCR1。CCL23(19-99)、CCL23(22-99)、CCL23(27-99)、CCL23(30-99)是比CCL23更有效的趋化因子。 {ECO:0000269|PubMed:15905581}。

组织特异性

High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients.

亚细胞定位

Secreted.

关键词

3D-structure Alternative splicing Chemotaxis Cytokine Direct protein sequencing Disulfide bond Heparin-binding Inflammatory response Proteomics identification Reference proteome