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CCL18 P55774

C-C基序趋化因子18 (替代巨噬细胞激活相关CC趋化因子1) (AMAC-1) (CC趋化因子PARC) (树突状细胞趋化因子1) (DC-CK1) (巨噬细胞炎症蛋白4) (MIP-4) (肺和激活调节趋化因子) (小诱导细胞因子A18) [裂解为:CCL18(1-68);CCL18(3-69);CCL18(4-69)]

蛋白质信息 (UniProt)

C-C基序趋化因子18 (替代巨噬细胞激活相关CC趋化因子1) (AMAC-1) (CC趋化因子PARC) (树突状细胞趋化因子1) (DC-CK1) (巨噬细胞炎症蛋白4) (MIP-4) (肺和激活调节趋化因子) (小诱导细胞因子A18) [裂解为:CCL18(1-68);CCL18(3-69);CCL18(4-69)]

P55774

功能描述

趋化因子,吸引淋巴细胞但不吸引单核细胞或粒细胞。可能参与B细胞迁移进入淋巴结中的B细胞滤泡。在淋巴结中吸引初始T淋巴细胞向树突状细胞和活化的巨噬细胞移动,对初始T细胞、CD4+和CD8+ T细胞具有趋化活性,因此可能在体液和细胞免疫应答中发挥作用。 {ECO:0000269|PubMed:11745396, ECO:0000269|PubMed:11978786}。

组织特异性

Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.

亚细胞定位

Secreted.

关键词

3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Inflammatory response Proteomics identification Reference proteome Secreted Signal