C-C基序趋化因子16 (趋化因子CC-4) (HCC-4) (趋化因子LEC) (IL-10诱导型趋化因子) (LCC-1) (肝表达趋化因子) (淋巴细胞和单核细胞趋化剂) (LMC) (单趋化蛋白-1) (MTN-1) (NCC-4) (小诱导细胞因子A16)
C-C基序趋化因子16 (趋化因子CC-4) (HCC-4) (趋化因子LEC) (IL-10诱导型趋化因子) (LCC-1) (肝表达趋化因子) (淋巴细胞和单核细胞趋化剂) (LMC) (单趋化蛋白-1) (MTN-1) (NCC-4) (小诱导细胞因子A16)
O15467功能描述
对淋巴细胞和单核细胞显示趋化活性，但对中性粒细胞无活性。亦显示强效的骨髓抑制活性，抑制髓系祖细胞的增殖。重组SCYA16对单核细胞和THP-1单核细胞显示趋化活性，但对静止淋巴细胞和中性粒细胞无活性。在经RANTES预先表达脱敏的THP-1细胞中诱导钙通量。
组织特异性
Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
亚细胞定位
Secreted.
关键词