CCKBR P32239

胃泌素/胆囊收缩素B型受体 (CCK-B受体) (CCK-BR) (胆囊收缩素-2受体) (CCK2-R)

功能描述

肽激素胃泌素和胆囊收缩素(CCK)的受体。在中枢神经系统广泛表达，调节焦虑、镇痛、觉醒和抗精神病活动等过程。偶联GNAI1和GNAQ信号通路，但不偶联GNAS (PubMed:34556863)。经胃泌素激活后，通过抑制PI3K/Akt/eIF4B通路下调SGLT1和GLUT2的表达，从而减少肠上皮细胞对葡萄糖的吸收 (By similarity)。在肾脏中，在高糖条件下通过ERK/NF-kappa-B信号降低SGLT2的表达 (By similarity)。 {ECO:0000250|UniProtKB:P56481, ECO:0000269|PubMed:34556863, ECO:0000269|PubMed:35672283}.; FUNCTION: Isoform 2呈组成型激活状态，可能通过不依赖胃泌素的机制调节癌细胞增殖。

组织特异性

Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.

亚细胞定位

Cell membrane; Multi-pass membrane protein.