CAV2 P51636

小窝蛋白-2

功能描述

可能在小窝膜内充当支架蛋白。直接与G蛋白α亚基相互作用，并在功能上调节其活性。作为辅助蛋白与CAV1协同作用，靶向脂筏并驱动小窝形成。Ser-36磷酸化形式在内皮细胞中具有调节有丝分裂的作用。MAPK信号通路细胞有丝分裂的正调节因子。胰岛素刺激MAPK1和STAT3的核转位及活化，以及随后的细胞周期进程调控所必需的(By similarity)。 {ECO:0000250, ECO:0000269|PubMed:15504032, ECO:0000269|PubMed:18081315}。

组织特异性

Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.

亚细胞定位

Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.