半胱天冬酶-14 (CASP-14) (EC 3.4.22.-) [剪切为：半胱天冬酶-14亚基p17，成熟形式；半胱天冬酶-14亚基p10，成熟形式；半胱天冬酶-14亚基p20，中间形式；半胱天冬酶-14亚基p8，中间形式]
半胱天冬酶-14 (CASP-14) (EC 3.4.22.-) [剪切为：半胱天冬酶-14亚基p17，成熟形式；半胱天冬酶-14亚基p10，成熟形式；半胱天冬酶-14亚基p20，中间形式；半胱天冬酶-14亚基p8，中间形式]
P31944功能描述
参与表皮分化的非凋亡caspase。是表皮角质层中的主要caspase (PubMed:15556625)。似乎在角质形成细胞分化中发挥作用，并且是角质化所必需的。通过蛋白水解加工filaggrin调节表皮的成熟 (By similarity)。在体外对底物[WY]-X-X-D基序有偏好，并且对合成caspase底物WEHD-ACF有活性 (PubMed:16854378, PubMed:19960512)。参与表皮中prosaposin的加工 (By similarity)。可能参与视网膜色素上皮细胞屏障功能 (PubMed:25121097)。参与分化角质形成细胞中的DNA降解，可能是通过切割DFFA/ICAD导致DFFB/CAD的释放 (PubMed:24743736)。 {ECO:0000250|UniProtKB:O89094, ECO:0000269|PubMed:15301553, ECO:0000269|PubMed:15556625, ECO:0000269|PubMed:16854378, ECO:0000269|PubMed:19960512, ECO:0000269|PubMed:22825846, ECO:0000269|PubMed:24743736, ECO:0000305|PubMed:25121097}.
组织特异性
Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846).
亚细胞定位
Cytoplasm
关键词