CADPS2 Q86UW7

钙依赖性分泌激活蛋白2 (钙依赖性分泌激活蛋白2) (CAPS-2)

功能描述

钙结合蛋白，参与充满神经递质和神经肽的囊泡胞吐作用。可能在成熟分泌囊泡的生物生成或维持过程中作用于融合的上游。调节颗粒细胞的神经营养因子释放，从而在小脑发育过程中调节细胞分化和存活。可能特异性介导大致密核心囊泡(DCVs)和其他致密核心囊泡的Ca(2+)依赖性胞吐（通过相似性）。{ECO:0000250}。

组织特异性

Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.

亚细胞定位

Cytoplasmic vesicle membrane