电压依赖性钙通道亚基α-2/δ-2 (电压门控钙通道亚基α-2/δ-2) [裂解为：电压依赖性钙通道亚基α-2-2；电压依赖性钙通道亚基δ-2]
电压依赖性钙通道亚基α-2/δ-2 (电压门控钙通道亚基α-2/δ-2) [裂解为：电压依赖性钙通道亚基α-2-2；电压依赖性钙通道亚基δ-2]
Q9NY47功能描述
电压依赖性钙通道的alpha-2/delta亚基调节钙通道的钙电流密度和激活/失活动力学。作为P/Q型钙通道(CACNA1A)、N型(CACNA1B)、L型(CACNA1C OR CACNA1D)以及可能的T型(CACNA1G)的调节亚基 (PubMed:15111129, PubMed:23339110)。过表达诱导细胞凋亡。 {ECO:0000269|PubMed:12555074, ECO:0000269|PubMed:15111129, ECO:0000269|PubMed:23339110}。
组织特异性
Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.
亚细胞定位
Membrane
关键词