电压依赖性P/Q型钙通道α-1A亚基 (脑钙通道I) (BI) (钙通道，L型，α-1多肽同工型4) (电压门控钙通道α Cav2.1亚基)
电压依赖性P/Q型钙通道α-1A亚基 (脑钙通道I) (BI) (钙通道，L型，α-1多肽同工型4) (电压门控钙通道α Cav2.1亚基)
O00555功能描述
电压敏感性钙通道 (VSCC) 介导钙离子进入可兴奋细胞，并参与多种钙依赖过程，包括肌肉收缩、激素或神经递质释放、基因表达、细胞运动、细胞分裂和细胞死亡。亚型 alpha-1A 产生 P 和/或 Q 型钙电流。P/Q 型钙通道属于“高压激活”(HVA) 组，并被蜘蛛毒素 omega-agatoxin-IVA (AC P54282) 特异性阻断 (By similarity)。然而，它们对二氢吡啶 (DHP) 不敏感。 {ECO:0000250|UniProtKB:P54282, ECO:0000269|PubMed:10049321, ECO:0000269|PubMed:10753886, ECO:0000269|PubMed:11723274, ECO:0000269|PubMed:15293273, ECO:0000269|PubMed:19232643, ECO:0000269|PubMed:24836863, ECO:0000269|PubMed:26716990}。
组织特异性
Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
亚细胞定位
Cell membrane
关键词