C3AR1 Q16581

C3a过敏毒素趋化受体 (C3AR) (C3a-R)

功能描述

趋化性和炎性肽过敏毒素C3a的受体，刺激趋化性、颗粒酶释放和超氧阴离子产生 (PubMed:12871936, PubMed:37852260, PubMed:8702752)。配体结合引起构象改变，通过鸟苷酸结合蛋白 (G蛋白) 触发信号传导，并调节下游效应子（如腺苷酸环化酶）的活性 (PubMed:37852260)。C3AR1与G(i)/G(o) (GNAI1或GNAO1) G alpha蛋白偶联，介导腺苷酸环化酶的抑制 (PubMed:37852260)。 {ECO:0000269|PubMed:12871936, ECO:0000269|PubMed:37852260, ECO:0000269|PubMed:8702752}。

组织特异性

Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells (PubMed:8605247, PubMed:8765043, Ref.3). Mostly expressed in lymphoid tissues (PubMed:8605247, PubMed:8765043, Ref.3).

亚细胞定位

Cell membrane