BIRC7 Q96CA5

杆状病毒IAP重复包含蛋白7 (EC 2.3.2.27) (肾凋亡抑制蛋白) (KIAP) (Livin) (黑色素瘤凋亡抑制蛋白) (ML-IAP) (环指蛋白50) (RING型E3泛素转移酶BIRC7) [剪切为：杆状病毒IAP重复包含蛋白7 30kDa亚基 (截短型Livin) (p30-Livin) (tLivin)]

功能描述

凋亡调节因子，能够发挥促凋亡和抗凋亡活性，并在凋亡、细胞增殖和细胞周期控制中起关键作用 (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084)。其抗凋亡活性通过抑制CASP3、CASP7和CASP9，以及其E3泛素-蛋白连接酶活性介导 (PubMed:11024045, PubMed:16729033)。由于它是弱caspase抑制剂，其抗凋亡活性被认为归因于其泛素化DIABLO/SMAC并使其靶向降解的能力，从而促进细胞存活 (PubMed:16729033)。可能通过阻断DIABLO/SMAC破坏XIAP/BIRC4-caspase相互作用的能力，从而有助于caspase抑制 (PubMed:16729033)。防止由TNF或化学试剂（如阿霉素、依托泊苷或星形孢菌素）诱导的凋亡 (PubMed:11084335, PubMed:11162435, PubMed:11865055)。凋亡抑制通过激活MAPK8/JNK1，可能还有MAPK9/JNK2介导 (PubMed:11865055)。这种激活依赖于TAB1和MAP3K7/TAK1 (PubMed:11865055)。在体外，抑制CASP3和pro-CASP9的蛋白水解激活 (PubMed:11024045)。 {ECO:0000269|PubMed:11024045, ECO:0000269|PubMed:11084335, ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11865055, ECO:0000269|PubMed:16729033, ECO:0000269|PubMed:17294084}.; FUNCTION: [Isoform 1]: 阻断星形孢菌素诱导的凋亡 (PubMed:11322947)。促进自然杀伤(NK)细胞介导的杀伤 (PubMed:18034418)。 {ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}.; FUNCTION: [Isoform 2]: 阻断依托泊苷诱导的凋亡 (PubMed:11162435, PubMed:11322947)。防止自然杀伤(NK)细胞介导的杀伤 (PubMed:18034418)。 {ECO:0000269|PubMed:11162435, ECO:0000269|PubMed:11322947, ECO:0000269|PubMed:18034418}.

组织特异性

Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.

亚细胞定位

Nucleus