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BIN2 Q9UBW5

整合素连接蛋白2 (乳腺癌相关蛋白1)

蛋白质信息 (UniProt)

整合素连接蛋白2 (乳腺癌相关蛋白1)

Q9UBW5

功能描述

功能:促进细胞运动和迁移,可能通过与细胞膜及介导与细胞骨架相互作用的podosome蛋白的相互作用来实现。调节膜曲率并介导膜管状化。在podosome形成中发挥作用。抑制吞噬作用。 {ECO:0000269|PubMed:23285027}。

组织特异性

Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Cell junction Cell membrane Cell projection Coiled coil Cytoplasm Membrane Phosphoprotein Proteomics identification