BCL2L2 Q92843

Bcl-2样蛋白2 (Bcl2-L-2) (细胞凋亡调节因子Bcl-W)

功能描述

促进细胞存活。阻断地塞米松诱导的细胞凋亡。通过抑制BAX的促死亡活性，介导有丝分裂后Sertoli细胞的存活。 {ECO:0000269|PubMed:8761287}。

组织特异性

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.

亚细胞定位

Mitochondrion membrane