BCAS3 Q9H6U6

BCAS3 微管相关细胞迁移因子 (乳腺癌扩增序列3) (GAOB1)

功能描述

在血管生成中发挥作用。通过介导CDC42的激活和募集以及细胞前沿肌动蛋白细胞骨架的重组，参与细胞极性和内皮细胞定向迁移的调节。促进丝状伪足形成（通过相似性）。与PELP1协同作用，作为雌激素受体应答基因的转录共激活因子。刺激组蛋白乙酰转移酶活性。结合染色质。在自噬活性中发挥调节作用。与PHAF1形成复合物，在非选择性自噬和选择性自噬过程中与自噬前体结构相关联 (PubMed:33499712)。可能结合磷脂酰肌醇3-磷酸 (PtdIns3P)，这介导了自噬前体结构的募集 (PubMed:33499712)。 {ECO:0000250|UniProtKB:Q8CCN5, ECO:0000269|PubMed:17505058, ECO:0000269|PubMed:33499712}。

组织特异性

Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.

亚细胞定位

Nucleus