BCAR1 P56945

乳腺癌抗雌激素耐药蛋白1 (CRK相关底物) (Cas支架蛋白家族成员1) (p130cas)

蛋白质信息 (UniProt)

乳腺癌抗雌激素耐药蛋白1 (CRK相关底物) (Cas支架蛋白家族成员1) (p130cas)

P56945

功能描述

Docking protein，在与细胞粘附相关的酪氨酸激酶信号传导中发挥中心协调作用 (PubMed:12432078, PubMed:12832404)。参与诱导细胞迁移和细胞分支 (PubMed:12432078, PubMed:12832404, PubMed:17038317)。参与BCAR3介导的TGFB信号传导抑制 (By similarity)。 {ECO:0000250|UniProtKB:Q61140, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:12832404, ECO:0000269|PubMed:17038317}。

组织特异性

Expressed in B-cells (at protein level) (PubMed:9020138). Widely expressed with an abundant expression in the testis (PubMed:10639512). Low level of expression seen in the liver, thymus, and peripheral blood leukocytes (PubMed:10639512).

亚细胞定位

Cell junction, focal adhesion

关键词

3D-structure Acetylation Alternative splicing Cell adhesion Cell junction Cell projection Cytoplasm Diabetes mellitus Direct protein sequencing Phosphoprotein

外部链接

UniProt: P56945

NCBI Gene

GeneCards