BAG1 Q99933

BAG家族分子伴侣调节蛋白1 (BAG-1) (Bcl-2相关athanogene 1)

功能描述

HSP70和HSC70 chaperone proteins的辅伴侣蛋白。作为核苷酸交换因子(NEF)促进ADP从HSP70和HSC70蛋白中释放，从而触发client/substrate蛋白的释放。核苷酸释放是通过其与HSPA8/HSC70的核苷酸结合结构域(NBD)结合介导的，而底物释放是通过其与HSPA8/HSC70的底物结合结构域(SBD)结合介导的(PubMed:24318877, PubMed:27474739, PubMed:9873016)。抑制PPP1R15A的促凋亡功能，并具有抗凋亡活性(PubMed:12724406)。显著增强BCL2由各种刺激诱导的抗细胞死亡功能(PubMed:9305631)。参与响应年龄相关的循环雌二醇(17-beta-estradiol/E2)下降而进行的ESR1的STUB1介导的蛋白酶体降解，从而促进缺血再灌注损伤后的神经元凋亡(By similarity)。 {ECO:0000250|UniProtKB:B0K019, ECO:0000269|PubMed:12724406, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:9305631, ECO:0000269|PubMed:9873016}.

组织特异性

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).

亚细胞定位

[Isoform 1]: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.