β-分泌酶 2 (EC 3.4.23.45) (类天冬氨酸蛋白酶 56 kDa) (天冬氨酸蛋白酶 1) (ASP1) (Asp 1) (β-位点淀粉样前体蛋白裂解酶 2) (β-位点APP裂解酶 2) (Down区天冬氨酸蛋白酶) (DRAP) (膜蛋白酶-1) (膜相关天冬氨酸蛋白酶 1) (θ-分泌酶)
β-分泌酶 2 (EC 3.4.23.45) (类天冬氨酸蛋白酶 56 kDa) (天冬氨酸蛋白酶 1) (ASP1) (Asp 1) (β-位点淀粉样前体蛋白裂解酶 2) (β-位点APP裂解酶 2) (Down区天冬氨酸蛋白酶) (DRAP) (膜蛋白酶-1) (膜相关天冬氨酸蛋白酶 1) (θ-分泌酶)
Q9Y5Z0功能描述
负责淀粉样前体蛋白 (APP) 的蛋白水解加工。在残基690和691之间切割APP，导致β切割的可溶性APP的生成和胞外释放，以及相应的细胞相关C末端片段，该片段随后被γ-分泌酶释放。研究也表明它可以在残基671和672之间切割APP (PubMed:10591213, PubMed:11083922, PubMed:11423558, PubMed:15857888, PubMed:16816112)。参与黑色素体生物发生早期阶段PMEL的蛋白水解脱落。在M-β片段内切割PMEL，以释放含有M-α和一小部分M-β N端的淀粉样蛋白生成性PMEL腔内片段。这是PMEL原纤维随后加工并组装成淀粉样蛋白片的先决条件 (PubMed:23754390)。也负责胰腺β细胞中CLTRN的蛋白水解加工 (PubMed:21907142)。 {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112, ECO:0000269|PubMed:21907142, ECO:0000269|PubMed:23754390}。
组织特异性
Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
亚细胞定位
Cell membrane
关键词