AZI2 Q9H6S1

5-氮杂胞苷诱导蛋白2 (NF-κB激活激酶相关蛋白1) (Nak相关蛋白1) (Nap1) (TILP)

蛋白质信息 (UniProt)

5-氮杂胞苷诱导蛋白2 (NF-κB激活激酶相关蛋白1) (Nak相关蛋白1) (Nap1) (TILP)

Q9H6S1

功能描述

结合TBK1和IKBKE的衔接蛋白，在抗病毒先天免疫中发挥作用 (PubMed:14560022, PubMed:21931631)。激活丝氨酸/苏氨酸蛋白激酶TBK1并促进其寡聚化 (PubMed:14560022, PubMed:21931631)。增强TBK1对NF-kappa-B p65亚基RELA的磷酸化 (PubMed:14560022, PubMed:21931631)。促进TBK1诱导以及TNF或PMA诱导的NF-kappa-B活化 (PubMed:14560022, PubMed:21931631)。通过TICAM1参与IFNB启动子的激活 (PubMed:15611223)。 {ECO:0000269|PubMed:14560022, ECO:0000269|PubMed:15611223, ECO:0000269|PubMed:21931631}。

组织特异性

Widely expressed (PubMed:14560022). Abundant expression seen in the pancreas and testis (PubMed:14560022).

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing Coiled coil Cytoplasm Host-virus interaction Phosphoprotein Proteomics identification Reference proteome Ubl conjugation

外部链接

UniProt: Q9H6S1

NCBI Gene

GeneCards