AWAT1 Q58HT5

酰基辅酶A蜡醇酰基转移酶1 (EC 2.3.1.75) (二酰甘油O-酰基转移酶2样蛋白3) (二酰甘油酰基转移酶2) (长链醇O-脂肪酰基转移酶1)

功能描述

酰基转移酶，催化脂肪醇和脂肪酰基CoA之间形成酯键以生成蜡单酯 (PubMed:15671038)。对癸醇 (C10) 表现出强烈的偏好，对C16和C18醇的活性较低 (PubMed:15671038)。对饱和酰基CoA表现出强烈的偏好 (PubMed:15671038)。 {ECO:0000269|PubMed:15671038}。

组织特异性

Predominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis.

亚细胞定位

Endoplasmic reticulum membrane