肌浆网/内质网钙ATP酶 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (钙泵 2) (肌浆网型钙转运ATP酶，慢速骨骼肌亚型) (内质网1/2类Ca(2+) ATP酶)
肌浆网/内质网钙ATP酶 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (钙泵 2) (肌浆网型钙转运ATP酶，慢速骨骼肌亚型) (内质网1/2类Ca(2+) ATP酶)
P16615功能描述
这种镁依赖性酶催化ATP的水解，同时伴随着钙从细胞质向肌浆网腔的转运 (PubMed:12542527, PubMed:16402920)。参与饥饿诱导的自噬。与VMP1相互作用并被激活后，控制用于自噬体形成的ER-隔离膜接触 (PubMed:28890335)。也调节ER与脂滴、线粒体和内体之间的接触 (PubMed:28890335)。与FLVCR2协同，介导血红素刺激的从线粒体ATP合成到产热的转换 (By similarity)。 {ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:12542527, ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: 参与收缩/舒张周期的调节。作为TNFSF11介导的Ca(2+)信号通路的调节因子，通过与TMEM64的相互作用发挥作用，这对于TNFSF11诱导的CREB1激活和破骨细胞正常生成所需的线粒体ROS产生至关重要。ER中TMEM64和SERCA2之间的关联导致胞质Ca(2+)峰值，从而激活NFATC1并产生线粒体ROS，进而触发促进破骨细胞分化和激活的Ca(2+)信号级联反应。 {ECO:0000250|UniProtKB:O55143}.
组织特异性
Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart.
亚细胞定位
Endoplasmic reticulum membrane
关键词