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ATP2A1 O14983

肌浆网/内质网钙ATP酶 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (钙泵 1) (肌浆网型钙转运ATP酶,快骨骼肌亚型) (内质网1/2类Ca(2+) ATP酶)

蛋白质信息 (UniProt)

肌浆网/内质网钙ATP酶 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (钙泵 1) (肌浆网型钙转运ATP酶,快骨骼肌亚型) (内质网1/2类Ca(2+) ATP酶)

O14983

功能描述

作为负责将细胞质Ca(2+)重摄取到肌浆网的主要Ca(2+) ATPase,是横纹肌性能的关键调节因子。催化ATP水解并伴随钙从细胞质转运至肌浆网腔(By similarity)。参与肌肉兴奋/收缩相关的钙螯合(PubMed:10914677)。 {ECO:0000250|UniProtKB:P04191, ECO:0000269|PubMed:10914677}。

组织特异性

Skeletal muscle, fast twitch muscle (type II) fibers.

亚细胞定位

Endoplasmic reticulum membrane

关键词

Alternative splicing ATP-binding Calcium Calcium transport Disease variant Disulfide bond Endoplasmic reticulum Ion transport Magnesium Membrane