ASMT P46597

乙酰血清素O-甲基转移酶 (EC 2.1.1.4) (羟基吲哚O-甲基转移酶) (HIOMT)

蛋白质信息 (UniProt)

乙酰血清素O-甲基转移酶 (EC 2.1.1.4) (羟基吲哚O-甲基转移酶) (HIOMT)

P46597

功能描述

[Isoform 1]: 催化甲基转移至N-乙酰血清素，生成褪黑素 (N-乙酰-5-甲氧基色胺)。 {ECO:0000269|PubMed:22775292}.; FUNCTION: [Isoform 2]: 不显示乙酰血清素O-甲基转移酶活性。 {ECO:0000269|PubMed:22775292}.; FUNCTION: [Isoform 3]: 不显示乙酰血清素O-甲基转移酶活性。 {ECO:0000269|PubMed:22775292}.

组织特异性

Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683).

关键词

3D-structure Alternative splicing Lipid metabolism Melatonin biosynthesis Methyltransferase Proteomics identification Reference proteome S-adenosyl-L-methionine Transferase

外部链接

UniProt: P46597

NCBI Gene

GeneCards