ADP核糖基化因子样蛋白3
ADP核糖基化因子样蛋白3
P36405功能描述
小GTP结合蛋白，在非活性GDP结合形式和活性GTP结合形式之间循环，其循环速率受鸟嘌呤核苷酸交换因子(GEF)和GTP酶激活蛋白(GAP)调节 (PubMed:16525022, PubMed:18588884)。正常的胞质分裂和纤毛信号传导所必需 (PubMed:22085962)。需要GTP酶激活蛋白(GAP)如RP2和PDE6D的协助，以便在非活性GDP结合形式和活性GTP结合形式之间循环。将蛋白质靶向纤毛所必需，包括肉豆蔻酰化NPHP3和异戊二烯化INPP5E (PubMed:30269812)。通过将肉豆脂酰化NPHP3从UNC119B货物适配器释放到纤毛中，将NPHP3靶向纤毛膜 (PubMed:22085962)。PKD1:PKD2复合物从反式高尔基体网络靶向纤毛所必需 (By similarity)。 {ECO:0000250|UniProtKB:Q9WUL7, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}。
组织特异性
Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level).
亚细胞定位
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium
关键词