Rho鸟嘌呤核苷酸交换因子4 (APC刺激的鸟嘌呤核苷酸交换因子1) (Asef) (Asef1)
Rho鸟嘌呤核苷酸交换因子4 (APC刺激的鸟嘌呤核苷酸交换因子1) (Asef) (Asef1)
Q9NR80功能描述
作为RHOA、RAC1和CDC42 GTPases的鸟嘌呤核苷酸交换因子(GEF)。APC的结合可能激活RAC1 GEF活性。APC-ARHGEF4复合物似乎参与细胞迁移以及E-cadherin介导的细胞间粘附。在结直肠肿瘤细胞中，通过JNK信号通路参与MMP9的上调。参与肿瘤血管生成，并可能在肠腺瘤形成和肿瘤进展中发挥作用。 {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}。
组织特异性
Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors.
亚细胞定位
[Isoform 3]: Cytoplasm. Cell projection, ruffle membrane
关键词