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ARHGAP32 A7KAX9

Rho GTPase激活蛋白32 (脑特异性Rho GTPase激活蛋白) (GAP相关Cdc42/Rac GTPase激活蛋白) (GC-GAP) (与TrkA相互作用的GTPase调节因子) (Rho型GTPase激活蛋白32) (Rho/Cdc42/Rac GTPase激活蛋白RICS) (参与β-连环蛋白-N-钙黏蛋白和NMDA受体信号通路的RhoGAP) (p200RhoGAP) (p250GAP)

蛋白质信息 (UniProt)

Rho GTPase激活蛋白32 (脑特异性Rho GTPase激活蛋白) (GAP相关Cdc42/Rac GTPase激活蛋白) (GC-GAP) (与TrkA相互作用的GTPase调节因子) (Rho型GTPase激活蛋白32) (Rho/Cdc42/Rac GTPase激活蛋白RICS) (参与β-连环蛋白-N-钙黏蛋白和NMDA受体信号通路的RhoGAP) (p200RhoGAP) (p250GAP)

A7KAX9

功能描述

GTPase激活蛋白(GAP),促进RHOA、CDC42和RAC1小GTP酶上的GTP水解。可能参与神经元细胞在神经突延伸形成过程中的分化。参与树突棘中NMDA受体活性依赖性的肌动蛋白重组。可能介导细胞生长调节中Ras和Rho调节信号通路之间的串扰。Isoform 2具有较高的GAP活性(通过相似性)。{ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}。

组织特异性

Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.

亚细胞定位

Postsynaptic density

关键词

3D-structure Alternative splicing Cell projection Cytoplasm Endoplasmic reticulum Endosome Golgi apparatus GTPase activation Membrane Methylation