ARHGAP29 Q52LW3

Rho GTPase激活蛋白29 (PTPL1关联RhoGAP蛋白1) (Rho型GTPase激活蛋白29)

蛋白质信息 (UniProt)

Rho GTPase激活蛋白29 (PTPL1关联RhoGAP蛋白1) (Rho型GTPase激活蛋白29)

Q52LW3

功能描述

Rho型GTPases的GTPase激活剂，通过将其转化为非活性的GDP结合状态。对RHOA具有强活性，对RAC1和CDC42活性较弱。可能作为RAP2A的特定效应因子来调节Rho。与RASIP1协同，抑制内皮细胞中的RhoA信号传导并减弱ROCK和MYH9活性，在血管管腔形成中发挥重要作用。 {ECO:0000269|PubMed:15752761, ECO:0000269|PubMed:9305890}。

组织特异性

Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney.

关键词

Alternative splicing Coiled coil Direct protein sequencing GTPase activation Metal-binding Phosphoprotein Proteomics identification Reference proteome Zinc Zinc-finger

外部链接

UniProt: Q52LW3

NCBI Gene

GeneCards