Rho GTPase激活蛋白21 (Rho GTPase-activating protein 10) (Rho型GTPase激活蛋白21)
Rho GTPase激活蛋白21 (Rho GTPase-activating protein 10) (Rho型GTPase激活蛋白21)
Q5T5U3功能描述
作为RHOA和CDC42的GTP酶激活蛋白(GAP)发挥作用。是ARF1的下游搭档，可能控制高尔基体结构和功能。也是CTNNA1募集至粘附连接所必需的。 {ECO:0000269|PubMed:15793564, ECO:0000269|PubMed:16184169}。
组织特异性
Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.
亚细胞定位
Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
关键词