DNA dC->dU编辑酶APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1)
DNA dC->dU编辑酶APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1)
P31941功能描述
DNA脱氨酶（胞嘧啶脱氨酶），对病毒、外源DNA和逆转录转座子的移动具有限制活性。对腺相关病毒（AAV）和人T细胞白血病病毒1型（HTLV-1）表现出抗病毒活性，并可能抑制LTR和非LTR逆转录转座子的移动。选择性靶向单链DNA，并能脱氨外源DNA中的甲基胞嘧啶和胞嘧啶。可在细胞核和线粒体DNA中诱导体细胞超突变。可能还通过主动DNA去甲基化过程在基因表达的表观遗传调控中发挥作用。 {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.
组织特异性
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.
亚细胞定位
Nucleus. Cytoplasm.
关键词