APOA1 P02647

载脂蛋白A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [裂解为：前载脂蛋白A-I (ProapoA-I)；截短载脂蛋白A-I (Apolipoprotein A-I(1-242))]

功能描述

参与胆固醇从组织到肝脏的逆向转运以进行排泄，通过促进胆固醇从组织流出并作为卵磷脂胆固醇酰基转移酶(LCAT)的辅因子发挥作用。作为SPAP复合物的一部分，激活精子运动。{ECO:0000269|PubMed:1909888}。

组织特异性

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.

亚细胞定位

Secreted.