γ-分泌酶亚基 APH-1A (APH-1a) (Aph-1alpha) (早老蛋白稳定因子)
γ-分泌酶亚基 APH-1A (APH-1a) (Aph-1alpha) (早老蛋白稳定因子)
Q96BI3功能描述
γ-分泌酶复合物的非催化亚基，该复合物是一种内切蛋白酶复合物，催化整合膜蛋白（如Notch受体和APP（淀粉样前体蛋白））的膜内切割 (PubMed:12297508, PubMed:12522139, PubMed:12679784, PubMed:12763021, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874)。为正常的γ-分泌酶组装所必需 (PubMed:12471034, PubMed:12522139, PubMed:12763021, PubMed:19369254)。γ-分泌酶复合物在Notch和Wnt信号级联反应中发挥作用，并通过其在加工关键调控蛋白以及调节细胞质CTNNB1水平中的作用来调节下游过程 (Probable)。 {ECO:0000269|PubMed:12297508, ECO:0000269|PubMed:12471034, ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:12763021, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874, ECO:0000305}。
组织特异性
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level.
亚细胞定位
Endoplasmic reticulum membrane
关键词