APC P25054

腺瘤性结肠息肉病蛋白 (Protein APC) (息肉病缺失蛋白 2.5)

功能描述

肿瘤抑制因子。促进CTNNB1的快速降解，并作为负调控因子参与Wnt信号通路。APC的活性与其磷酸化状态相关。激活SPATA13和ARHGEF4的GEF活性。在肝细胞生长因子(HGF)诱导的细胞迁移中发挥作用。在结直肠肿瘤细胞中，通过JNK信号通路参与MMP9的上调。与细胞骨架的组分微管和肌动蛋白丝结合 (PubMed:17293347)。在介导F-肌动蛋白组织成有序束状结构中发挥作用 (PubMed:17293347)。位于Rho GTPases和DIAPH1下游发挥作用，选择性稳定微管 (By similarity)。作为ERBB2依赖性细胞皮层微管稳定的介导因子。它是MACF1定位至细胞膜所必需的，而MACF1的这种定位对其在微管稳定中的功能至关重要。 {ECO:0000250|UniProtKB:Q61315, ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17293347, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.

组织特异性

Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144).

亚细胞定位

Cell junction, adherens junction