胺氧化酶 [含铜] 3 (EC 1.4.3.21) (含铜胺氧化酶 3) (铜胺氧化酶) (HPAO) (氨基脲敏感性胺氧化酶) (SSAO) (血管粘附蛋白 1) (VAP-1)
胺氧化酶 [含铜] 3 (EC 1.4.3.21) (含铜胺氧化酶 3) (铜胺氧化酶) (HPAO) (氨基脲敏感性胺氧化酶) (SSAO) (血管粘附蛋白 1) (VAP-1)
Q16853功能描述
催化伯胺氧化脱氨生成相应的醛，同时产生过氧化氢和氨 (PubMed:19588076, PubMed:24304424, PubMed:9653080)。对伯单胺甲胺和苄胺具有偏好性 (PubMed:19588076, PubMed:9653080)。也可能作用于2-苯乙胺，但效率低得多 (PubMed:19588076)。在内皮细胞表面，还可以作为细胞粘附蛋白发挥作用，通过以不依赖L-选择素的方式介导淋巴细胞与外周淋巴结血管内皮细胞的结合，参与淋巴细胞外渗和再循环 (PubMed:9254657, PubMed:9653080)。 {ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:24304424, ECO:0000269|PubMed:9254657, ECO:0000269|PubMed:9653080}.; FUNCTION: [Isoform 2]: 无氨基脲敏感性胺氧化酶 (SSAO) 活性。 {ECO:0000269|PubMed:23349812}.
组织特异性
Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung.
亚细胞定位
Cell membrane
关键词