返回首页

ANKS1B Q7Z6G8

锚蛋白重复序列和无菌α模体结构域包含蛋白1B (淀粉样β蛋白胞内结构域相关蛋白1) (AIDA-1) (E2A-PBX1相关蛋白) (EB-1)

蛋白质信息 (UniProt)

锚蛋白重复序列和无菌α模体结构域包含蛋白1B (淀粉样β蛋白胞内结构域相关蛋白1) (AIDA-1) (E2A-PBX1相关蛋白) (EB-1)

Q7Z6G8

功能描述

Isoform 2可能参与神经元和转化细胞中核质coilin蛋白相互作用的调节。; FUNCTION: Isoform 3能通过改变核仁数量来调节全局蛋白合成。 {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4可能作为APP加工的调节因子发挥作用。过表达可下调APP加工。

组织特异性

Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.

亚细胞定位

Cytoplasm

关键词

3D-structure Alternative splicing ANK repeat Cell projection Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat