ALKAL1 Q6UXT8

ALK和LTK配体1 (Augmentor beta) (AUG-beta)

蛋白质信息 (UniProt)

ALK和LTK配体1 (Augmentor beta) (AUG-beta)

Q6UXT8

功能描述

作为受体酪氨酸激酶LTK的生理性配体发挥作用的细胞因子，导致其激活 (PubMed:25331893, PubMed:26418745, PubMed:26630010, PubMed:34646012, PubMed:34819673)。单体ALKAL1结合LTK，导致LTK同源二聚化和激活 (PubMed:34646012, PubMed:34819673)。与ALKAL2不同，不作为ALK的有效生理性配体发挥作用 (PubMed:26418745, PubMed:34646012)。 {ECO:0000269|PubMed:25331893, ECO:0000269|PubMed:26418745, ECO:0000269|PubMed:26630010, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}。

组织特异性

Widely expressed with highest levels in thyroid and moderate levels in stomach, trachea, small intestine, prostate and brain.

亚细胞定位

Secreted

关键词

3D-structure Alternative splicing Cell membrane Cytokine Disulfide bond Membrane Proteomics identification Reference proteome Secreted Signal

外部链接

UniProt: Q6UXT8

NCBI Gene

GeneCards