AKNA Q7Z591

微管组织蛋白AKNA（含AT钩转录因子）

功能描述

中心体蛋白，通过调节微管组织在细胞分层中发挥关键作用 (By similarity)。神经发生过程中，侧脑室下区神经干细胞的分层和留存所必需的 (By similarity)。也调节其他上皮细胞的上皮-间充质转化 (By similarity)。通过增加中心体微管成核并募集成核因子和负端稳定因子发挥作用，从而破坏粘附连接处的微管稳定性并介导顶突的收缩 (By similarity)。此外，也可能作为转录因子，特异性激活CD40受体及其配体CD40L/CD154的表达，这两种淋巴细胞表面的分子对抗原依赖性B细胞发育至关重要 (PubMed:11268217)。结合富含A/T的启动子 (PubMed:11268217)。目前尚不清楚其如何同时作为微管组织者和转录因子发挥作用；需要更多证据来协调这两种明显矛盾的功能 (Probable)。 {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}。

组织特异性

Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.

亚细胞定位

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole