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AGPAT1 Q99943

1-酰基-sn-甘油-3-磷酸酰基转移酶α (EC 2.3.1.51) (1-酰基甘油-3-磷酸O-酰基转移酶1) (1-AGP酰基转移酶1) (1-AGPAT 1) (溶血磷脂酸酰基转移酶α) (LPAAT-alpha) (蛋白G15)

蛋白质信息 (UniProt)

1-酰基-sn-甘油-3-磷酸酰基转移酶α (EC 2.3.1.51) (1-酰基甘油-3-磷酸O-酰基转移酶1) (1-AGP酰基转移酶1) (1-AGPAT 1) (溶血磷脂酸酰基转移酶α) (LPAAT-alpha) (蛋白G15)

Q99943

功能描述

通过在甘油骨架的sn-2位引入酰基部分,将1-酰基-sn-甘油-3-磷酸(溶血磷脂酸或LPA)转化为1,2-二酰基-sn-甘油-3-磷酸(磷脂酸或PA)。 {ECO:0000269|PubMed:21873652, ECO:0000269|PubMed:9461603}。

组织特异性

Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.

亚细胞定位

Endoplasmic reticulum membrane

关键词

Acyltransferase Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Phospholipid biosynthesis Phospholipid metabolism Proteomics identification Reference proteome Signal