ADSL P30566

腺苷酸琥珀酸裂解酶 (ADSL) (ASL) (EC 4.3.2.2) (腺苷酸琥珀酸酶) (ASase)

功能描述

催化AMP从头合成中的两个非连续步骤：将(S)-2-(5-氨基-1-(5-磷酸-D-核糖基)咪唑-4-甲酰胺基)琥珀酸(SAICAR)转化为延胡索酸加5-氨基-1-(5-磷酸-D-核糖基)咪唑-4-甲酰胺，从而也促进IMP的从头合成，并将琥珀酰腺苷一磷酸(SAMP)转化为AMP和延胡索酸。 {ECO:0000269|PubMed:10888601}。

组织特异性

Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.